1 Result for "

BafA-1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "BafA-1" in MCE Product Catalog:

885
Bafilomycin A1
Bafilomycin A1
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885 Cited Publications
Cat. No.: HY-100558
CAS No.: 88899-55-2
Purity:  99.95%
Synonyms: BafA1
Category:  

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields

Target:  

Proton Pump Autophagy Antibiotic Bacterial Apoptosis

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H +-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis [1] .
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