3 Results for "

Bruceantinol

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Bruceantinol" in MCE Product Catalog:

Cat. No.: HY-N8146
CAS No.: 53729-52-5
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50 = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .
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Cat. No.: HY-N10897
CAS No.: 948038-36-6
Bruceantinol A, a natural compound, can be isolated from Brucea javanica seeds .
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Cat. No.: HY-N13474
CAS No.: 1822332-33-1
Bruceantinol B is a natural product .
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