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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
CBPD-268
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "CBPD-268" in MCE Product Catalog:
Cat. No.: HY-161369
CAS No.: 2832961-58-5
Target:
Research Areas:
CBPD-268 is a potent and orally active CBP/p300 PROTAC degrader with an DC50 value of ≤ 0.03 nM. CBPD-268 induces CBP/p300 degradation and inhibits cell growth. CBPD-268 shows antitumor activity. CBPD-268 has the potential for the research of AR-positive prostate cancer (Structure Note: Red, Androgen receptor degrader (HY-W248665A); Blue, CBP/p300 ligand (HY-161483); Black, Linker) .
Cat. No.: HY-177927
CAS No.: 2750072-14-9
Research Areas:
CBP-IN-1 acid is a CBP Inhibitor-Linker Conjugate composed of CBP-IN-1 (HY-153948) and a linker. CBP-IN-1 acid can be used to synthesize PROTACs, such as CBPD-268 (HY-161369) .
Cat. No.: HY-161483
CAS No.: 1936425-34-1
Research Areas:
CBP/p300 ligand 3 is a target protein ligand of CBPD-268 (HY-161369). CBP and p300 are two proteins with histone acetyltransferase (HAT) activity, and CBP and p300 play key roles in regulating biological processes such as gene expression, cell proliferation, differentiation and DNA repair. Through its acetyltransferase activity, CBP/p300 can acetylate histones and other proteins, thereby regulating chromatin structure and gene expression. CBP/p300 ligand 3 regulates the function of CBP/p300 by binding to a specific domain of the CBP/p300 protein (the bromine domain or HAT domain), inhibiting its enzyme activity or altering its interactions with other proteins (transcription factors). CBP/p300 ligand 3 can be used in cancer, neurodegenerative diseases and other disease models associated with abnormal CBP/p300 function .
Cat. No.: HY-187066
CAS No.: 2832964-54-0
Research Areas:
trans-CBP/p300 ligand 3-cyclohexane-CHO is a target protein ligand-linker conjugate. trans-CBP/p300 ligand 3-cyclohexane-CHO is used for the synthesis of PROTAC CBPD-268 (HY-161369) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
