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Cat. No.: HY-187066

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trans-CBP/p300 ligand 3-cyclohexane-CHO

trans-CBP/p300 ligand 3-cyclohexane-CHO is a target protein ligand-linker conjugate. trans-CBP/p300 ligand 3-cyclohexane-CHO is used for the synthesis of PROTAC CBPD-268 (HY-161369).

For research use only. We do not sell to patients.

CAS No.: 2832964-54-0
Formula: C₂₉H₃₄F₂N₆O₂
Molecular Weight:536.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

trans-CBP/p300 ligand 3-cyclohexane-CHO Chemical Structure

CAS No.: 2832964-54-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

trans-CBP/p300 ligand 3-cyclohexane-CHO is a target protein ligand-linker conjugate. trans-CBP/p300 ligand 3-cyclohexane-CHO is used for the synthesis of PROTAC CBPD-268 (HY-161369)^[1].

In Vitro

Target protein ligand-linker conjugates combine a target protein ligand with a linker. When bound to an E3 ligase ligand, the conjugate becomes a PROTAC capable of inducing ubiquitination and subsequent degradation of the target protein.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2832964-54-0
Molecular Weight 536.62
Formula C₂₉H₃₄F₂N₆O₂
SMILES

CC(N1CC2=C(CC1)N([C@@H]3CC[C@H](CC3)C=O)N=C2N4CCCC5=C4C=C(C(F)F)C(C6=CN(N=C6)C)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen Z, et al. Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression. Journal of medicinal chemistry. 2024 Apr 11;67(7):5275-5304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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trans-CBP/p300 ligand 3-cyclohexane-CHO

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trans-CBP/p300 ligand 3-cyclohexane-CHO

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

trans-CBP/p300 ligand 3-cyclohexane-CHO Related Classifications

HY-187066 Related Classifications

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