9 Results for "

CCK-B agonist

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "CCK-B agonist" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-A0261
CAS No.: 5534-95-2
Synonyms: ICI-50123
Research Areas:  

Metabolic Disease Cancer

Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCKB) receptor agonist with an EC50 value of 11 nM. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury .
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Cat. No.: HY-P1096
CAS No.: 130408-77-4
Research Areas:  

Metabolic Disease

A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively .
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Cat. No.: HY-177508
Research Areas:  

Neurological Disease

BC264 is a highly potent and selective CCK-B agonist that crosses the blood-brain barrier. BC264 increases dopamine in the nucleus accumbens and facilitates motivation and attention in rats .
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Cat. No.: HY-123434
CAS No.: 181941-32-2
Research Areas:  

Metabolic Disease Endocrinology

PD-149164 is a potent agonist of cholecystokinin B (CCK-B) receptor, with IC50 values of 0.083 nM and 75 nM in binding assay to CCK-B and CCK-A .
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Cat. No.: HY-111918
CAS No.: 127902-33-4
Research Areas:  

Metabolic Disease

A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM) .
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Cat. No.: HY-129516
CAS No.: 131449-37-1
Research Areas:  

Metabolic Disease

A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor .
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Cat. No.: HY-P2055
CAS No.: 125598-87-0
Target:  

Endogenous Metabolite

Research Areas:  

Endocrinology

A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM). A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay .
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Cat. No.: HY-A0261A
CAS No.: 57448-84-7
Synonyms: ICI-50123 meglumine
Research Areas:  

Metabolic Disease Cancer

Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor agonist with an EC50 value of 11 nM. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury .
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Cat. No.: HY-P1994A
CAS No.: 117829-60-4
Research Areas:  

Neurological Disease

JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L .
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