131449-37-1
Chemical Structure
A-70874
- CAS No.: 131449-37-1
- Formula:C45H55N7O10
- Molecular Weight:853.96
IUPAC Name: (6S,9S,12S)-6-((1H-indol-3-yl)methyl)-12-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)(methyl)carbamoyl)-9-(4-((E)-3-(4-hydroxyphenyl)acrylamido)butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatetradecan-14-oic acid
InChIKey: BERNHFOYDVXQGI-ZXLOHXMUSA-N
SMILES: NC([C@H](CC1=CC=CC=C1)N(C)C([C@H](CC(O)=O)NC([C@H](CCCCNC(/C=C/C2=CC=C(O)C=C2)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O
Biological Activity: A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor[1].
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A-70874 | A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor. | |||||||||||||||||||||
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