1 Result for "

CPI-1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "CPI-1" in MCE Product Catalog:

Cat. No.: HY-P10856
CAS No.: 3085809-95-3
Target:  

P-glycoprotein

Research Areas:  

Cancer

CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance [1].
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