3085809-95-3
Chemical Structure
CPI1
- CAS No.: 3085809-95-3
- Formula:C111H131N23O30S
- Molecular Weight:2299.43
InChIKey: VKDWYSICSHFUSA-OWOSNWKNSA-N
SMILES: O=C(CSC[C@H](NC1=O)C(O)=O)N[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CNC=N7)=O)CC(C)C)=O)CC(N)=O)=O)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=C(O)C=C%11
Biological Activity: CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance[1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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CPI1 | 99.30% | CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance. | ||||||||||||||||||||
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Antitumor agent-127 | 99.09% | Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines. | ||||||||||||||||||||
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Propeptin | Propeptin is a peptide antibiotic composed of 19 amino acids. Propeptin has weaker activity against Pseudomonas aeruginosa, Mycobacterium monobacterium, and Xanthomonas oryzae. Propeptin has no effect on KB and L1210 cells of tumor cell lines, but has an inhibitory effect on prolyl endopeptidase. | |||||||||||||||||||||
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Endothelin-3, human, mouse, rabbit, rat | 97.58% | Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis. | ||||||||||||||||||||
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Endothelin-2 (49-69), human | 99.86% | Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. | ||||||||||||||||||||
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G7-18NATE | G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines. | |||||||||||||||||||||
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Vasoactive intestinal contractor | Vasoactive intestinal contractor is a novel member of the endothelin family. Vasoactive intestinal contractor stimulates a rapid increase in the intracellular Ca2+ concentration in fura-2-overexpressed Swiss 3T3 cells[1. | |||||||||||||||||||||
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Ub4ix | 99.32% | Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM. |
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TrkA/NGF-IN-1 | 98.22% | TrkA/NGF-IN-1 (Peptide 19) is an inhibitor of protein-protein interactions between TrkA and NGF (IC50: 21 nM for human TrkA in PathHunter assay). TrkA/NGF-IN-1 shows an analgesic effect in a rat incisional pain model. | ||||||||||||||||||||
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Tyr-Somatostatin-14 | 99.09% | Tyr-Somatostatin-14 is a customized peptide that adds a Tyrosine amino acid to Somatostatin-14. | ||||||||||||||||||||
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[Ala2] Endothelin-3, human | [Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells. | |||||||||||||||||||||
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