3085809-95-3
Chemical Structure
CPI1
- CAS No.: 3085809-95-3
- Formula:C111H131N23O30S
- Molecular Weight:2299.43
InChIKey: VKDWYSICSHFUSA-OWOSNWKNSA-N
SMILES: O=C(CSC[C@H](NC1=O)C(O)=O)N[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CNC=N7)=O)CC(C)C)=O)CC(N)=O)=O)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=C(O)C=C%11
Biological Activity: CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CPI1 | 99.30% | CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance. | ||||||||||||||||||||
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Keywords
