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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Dabrafenib
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Dabrafenib" in MCE Product Catalog:
83
83
83 Cited Publications
Synonyms: GSK2118436 Mesylate; GSK 2118436B
Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC50s of 0.6 and 5.0 nM for Raf V600E and c-Raf, respectively.
Synonyms: (S,R,S)-AHPC-Me-PEG2-Dabrafenib
Target:
Research Areas:
DD-03-156 ((S,R,S)-AHPC-Me-PEG2-dabrafenib) is a VHL-based PROTAC degrader targeting CDK17 and LIMK2. DD-03-156 serves as an excellent lead-like starting point for the development of selective chemical probes targeting CDK17 degradation .
Cat. No.: HY-14660S
CAS No.: 1423119-98-5
Synonyms: GSK2118436A-d9; GSK2118436-d9
Cat. No.: HY-175659
CAS No.: 1195873-54-1
Target:
Research Areas:
Dabrafenib carboxylic acid is the carboxyl metabolite of dabrafenib (HY-14660) .
Cat. No.: HY-150639
CAS No.: 2923700-82-5
Everafenib is a potent and blood-brain barrier (BBB) penetrant BRAF inhibitor, also inhibits MAPK signaling. Everafenib has inhibitory activity against a panel of V600EBRAF melanoma cell lines with IC50 values of 2-10 nM, which is better than Dabrafenib (HY-14660) and Vemurafenib (HY-12057). Everafenib has efficacy in an intracranial mouse model of metastatic melanoma .
Cat. No.: HY-14660AR
CAS No.: 1195768-06-9
Synonyms: GSK2118436 Mesylate (Standard); GSK 2118436B (Standard)
Target:
Research Areas:
Dabrafenib (Mesylate) (Standard) is the analytical standard of Dabrafenib (Mesylate). This product is intended for research and analytical applications. Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively.
Cat. No.: HY-14660R
CAS No.: 1195765-45-7
Synonyms: GSK2118436A (Standard); GSK2118436 (Standard)
Target:
Research Areas:
Dabrafenib (Standard) is the analytical standard of Dabrafenib. This product is intended for research and analytical applications. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-Raf V600E, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
