1423119-98-5
Chemical Structure
Dabrafenib-d9
Synonym(s): GSK2118436A-d9;GSK2118436-d9
- CAS No.: 1423119-98-5
- Formula:C23H11D9F3N5O2S2
- Molecular Weight:528.62
IUPAC Name: N-(3-(5-(2-aminopyrimidin-4-yl)-2-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
InChIKey: BFSMGDJOXZAERB-GQALSZNTSA-N
SMILES: O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=N3)=C2F)=O
Biological Activity: Dabrafenib-d9 is the deuterium labeled Dabrafenib. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively[4].
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Dabrafenib-d9 | Dabrafenib-d9 is the deuterium labeled Dabrafenib. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively. | |||||||||||||||||||||
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Dabrafenib (Standard) | ≥98% | Dabrafenib (Standard) is the analytical standard of Dabrafenib. This product is intended for research and analytical applications. Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively. | ||||||||||||||||||||
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Dabrafenib | 99.94% | Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively. | ||||||||||||||||||||
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