2 Results for "

Drupanin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Drupanin" in MCE Product Catalog:

Cat. No.: HY-N10361
CAS No.: 53755-58-1
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .
loading...
    loading...
Cat. No.: HY-144749
CAS No.: 2839142-93-5
Research Areas:  

Cancer

AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells .
loading...
    loading...