53755-58-1
Chemical Structure
Drupanin
- CAS No.: 53755-58-1
- Formula:C14H16O3
- Molecular Weight:232.28
IUPAC Name: tert-butyl ((2S,3S)-4-([1,4'-bipiperidin]-1'-yl)-3-hydroxy-1-phenylbutan-2-yl)carbamate
InChIKey: HZKNHDLUFBYIQN-VMPITWQZSA-N
SMILES: C/C(C)=C\CC1=C(C=CC(/C=C/C(O)=O)=C1)O
Biological Activity: Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers[1][2][3].
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Drupanin | 99.35% | Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers. | ||||||||||||||||||||
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- [1]. Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021;47:116372. [Content Brief]
- [2]. Nakashima K, et al. Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis. Biochim Biophys Acta. 2014 Oct;1840(10):3034-41. [Content Brief]
- [3]. Mishima S, et al. Two related cinnamic Acid derivatives from Brazilian honey bee propolis, baccharin and drupanin, induce growth inhibition in allografted sarcoma S-180 in mice. Biol Pharm Bull. 2005 Jun;28(6):1025-30. [Content Brief]
Keywords
