2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. 2-Methyl-2-butenyl (E)-Caffeate

2-Methyl-2-butenyl (E)-Caffeate is a type of caffeic acid ester compound. The petroleum ether and chloroform extracts containing 2-Methyl-2-butenyl (E)-Caffeate have inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The ether extract containing 2-Methyl-2-butenyl (E)-Caffeate exhibits strong antioxidant properties. 2-Methyl-2-butenyl (E)-Caffeate can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

2-Methyl-2-butenyl (E)-Caffeate

2-Methyl-2-butenyl (E)-Caffeate Chemical Structure

CAS No. : 118971-61-2

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2-Methyl-2-butenyl (E)-Caffeate Related Antibodies

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Description

2-Methyl-2-butenyl (E)-Caffeate is a type of caffeic acid ester compound. The petroleum ether and chloroform extracts containing 2-Methyl-2-butenyl (E)-Caffeate have inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The ether extract containing 2-Methyl-2-butenyl (E)-Caffeate exhibits strong antioxidant properties. 2-Methyl-2-butenyl (E)-Caffeate can be used in the research of Alzheimer's disease[1].

IC50 & Target[1]

AChE

 

BChE

 

Cellular Effect
Cell Line Type Value Description References
RAW264.7 EC50
0.578 μM
Compound: 20, prenyl caffeate
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay
[PMID: 18667320]
RAW264.7 EC50
30 μM
Compound: 20, prenyl caffeate
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
[PMID: 18667320]
Molecular Weight

248.27

Formula

C14H16O4
CAS No.
SMILES

C/C(C)=C\COC(/C=C/C1=CC(O)=C(C=C1)O)=O
Structure Classification
Initial Source

Algerian propolis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Methyl-2-butenyl (E)-Caffeate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methyl-2-butenyl (E)-Caffeate118971-61-2Cholinesterase (ChE)Algerian propolischemical compositionantioxidant activityanticholinesterase activityphenolic compoundsflavonoidsacetylcholinesterase inhibitionnatural productsPopulus spp.Citrus sppInhibitorinhibitorinhibit

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2-Methyl-2-butenyl (E)-Caffeate
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