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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
EVT-401
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "EVT-401" in MCE Product Catalog:
Art. -Nr.: HY-145466
Reinheit: 99.89%
Target:
Forschungsgebiete:
(Rac)-EVT-401 (HY-145466) is the racemate of EVT-401 (HY-178230). (Rac)-EVT-401 is a P2X7 receptor antagonist that can be used in research related to rheumatoid arthritis .
Art. -Nr.: HY-178230
CAS. Nr.: 951015-69-3
Target:
Forschungsgebiete:
EVT-401 is an orally active, potent and highly selective human P2X7R antagonist, with an IC50 of 10 nM and a Ki of 7.6 nM for human P2X7R, and an IC50 of 220 nM for mouse P2X7R. EVT-401 promotes apoptosis and induces cell cycle arrest in human rheumatoid arthritis synovial fibroblasts (RA SF), reduces the production of proinflammatory and joint-destructive mediators, and mitigates aggressive phenotypes. EVT-401 exhibits favorable oral bioavailability and a good safety profile, making it suitable for research into rheumatoid arthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
