1 Result for "

Energy-coupling factor-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Energy-coupling factor-IN-1" in MCE Product Catalog:

Cat. No.: HY-184417
CAS No.: 3085883-97-9
Target:  

Bacterial

Research Areas:  

Infection

Energy-coupling factor-IN-1 is an energy-coupling factor (ECF) transporter inhibitor with an IC50 of 42.84 μM against ECF-FolT2. Energy-coupling factor-IN-1 binds to the interface between the S component and the ECF module, and inhibits the uptake of folic acid and pantothenic acid via the target transporter. Energy-coupling factor-IN-1 acts as a bactericidal agent, exerting rapid and sustained activity for 24 h against Enterococcus faecium, while also acting against Gram-positive bacteria including drug-resistant strains. Energy-coupling factor-IN-1 improves the survival rate of zebrafish embryos infected with Enterococcus faecium. Energy-coupling factor-IN-1 can be used in studies of Gram-positive bacterial infections .
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