3085883-97-9
Chemical Structure
Energy-coupling factor-IN-1
- CAS No.: 3085883-97-9
- Formula:C28H29ClN4O5
- Molecular Weight:537.01
InChIKey: KBHNQPNHOFMZND-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(OCC2=CC(C3=CC(Cl)=C(OC(C)C)N=C3)=CC(N4N=NC(C(C)(C)C)=C4)=C2)=CC=C1O
Biological Activity: Energy-coupling factor-IN-1 is an energy-coupling factor (ECF) transporter inhibitor with an IC50 of 42.84 μM against ECF-FolT2. Energy-coupling factor-IN-1 binds to the interface between the S component and the ECF module, and inhibits the uptake of folic acid and pantothenic acid via the target transporter. Energy-coupling factor-IN-1 acts as a bactericidal agent, exerting rapid and sustained activity for 24 h against Enterococcus faecium, while also acting against Gram-positive bacteria including drug-resistant strains. Energy-coupling factor-IN-1 improves the survival rate of zebrafish embryos infected with Enterococcus faecium. Energy-coupling factor-IN-1 can be used in studies of Gram-positive bacterial infections[1].
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Energy-coupling factor-IN-1 | Energy-coupling factor-IN-1 is an energy-coupling factor (ECF) transporter inhibitor with an IC50 of 42.84 μM against ECF-FolT2. Energy-coupling factor-IN-1 binds to the interface between the S component and the ECF module, and inhibits the uptake of folic acid and pantothenic acid via the target transporter. Energy-coupling factor-IN-1 acts as a bactericidal agent, exerting rapid and sustained activity for 24 h against Enterococcus faecium, while also acting against Gram-positive bacteria including drug-resistant strains. Energy-coupling factor-IN-1 improves the survival rate of zebrafish embryos infected with Enterococcus faecium. Energy-coupling factor-IN-1 can be used in studies of Gram-positive bacterial infections. | |||||||||||||||||||||
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Keywords
