Energy-coupling factor-IN-1

Energy-coupling factor-IN-1 (compound 36) potently inhibits ECF transporter-mediated substrate uptake in Lactobacillus casei whole cells with an IC₅₀ of 7 μM^[1].
Energy-coupling factor-IN-1 inhibits both ECF-FolT2 and ECF-PanT transporters in Lactobacillus delbrueckii proteoliposomes, with an IC₅₀ of 42.84 μM for ECF-FolT2 and near-complete inhibition of ECF-PanT at 150 μM^[1].
Energy-coupling factor-IN-1 exhibits potent antibacterial activity against a panel of Gram-positive bacteria, including vancomycin-resistant E. faecium and penicillin-resistant S. pneumoniae, with MIC values ranging from 0.5-4 μg/mL^[1].
Energy-coupling factor-IN-1 (17.2-68.8 μg/mL; 24 h) displays rapid, sustained bactericidal activity against multidrug-resistant Enterococcus faecium ATCC51559^[1].
Energy-coupling factor-IN-1 binds to the pantothenate-binding pocket of Streptococcus pneumoniae ECF-PanT, forming interactions with both the S-component and EcfT module residues to enhance binding affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.