5 Results for "

Fc crosslinking

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Fc crosslinking" in MCE Product Catalog:

Cat. No.: HY-P991402

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

BI-1910 is an agonistic human IgG2 monoclonal antibody targeting TNFR2, which selectively binds to human TNFR2 without inhibiting TNF-α binding. As an endogenous agonist, BI-1910 activates TNFR2 and mediates the activation of the NF-κB signaling pathway. Its agonistic activity is independent of FcγR or cross-linking; it can directly costimulate T cells and NK cells, induce T cell proliferation, and activate tumor-specific CD8+ T cells. BI-1910 exhibits antitumor activity in vivo, and shows an additive antitumor effect when combined with anti-PD-1 (HY-P9902). It can be used in research related to advanced/metastatic non-small cell lung cancer and hepatocellular carcinoma. Recommended isotype control: Human IgG2 lambda, Isotype Control (HY-P991206) .
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Cat. No.: HY-P991070

Target:  

TNF Receptor

Research Areas:  

Cancer

ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P3350
CAS No.: 2892148-58-0
Target:  

Bacterial

Research Areas:  

Infection

LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
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Cat. No.: HY-P992399

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

LBL-019 is a humanized IgG1 monoclonal antibody targeting TNFR2. LBL-019 costimulates TNFR2 and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .
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Cat. No.: HY-P992509
Synonyms: NCT02642016; KTN0158

Target:  

c-Kit

Research Areas:  

Cancer

CDX-0158 (NCT02642016; KTN0158) is a humanized anti-c-Kit/CD117 IgG1κ monoclonal antibody. CDX-0158 effectively blocks the SCF-KIT signaling pathway and inhibits mast cell activation, but due to the retention of wild-type IgG1 Fc, it can induce mast cell degranulation through FcyR cross-linking, resulting in obvious infusion reactions. CDX-0158 can be used in research related to advanced refractory gastrointestinal stromal tumors .
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