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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
GXF111
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "GXF111" in MCE Product Catalog:
Cat. No.: HY-153414
Target:
Research Areas:
GXF-111 is a BRD3 and BRD4-L PROTAC degrader. Its BD1 and BD2 Ki values against human BRD3 are 11.97 nM and 2.45 nM, respectively. The degradation activity of GXF-111 depends on its binding to BET proteins and Cereblon, as well as the involvement of a functional proteasome. The degradation selectivity of GXF-111 is mainly determined by differences in degradation kinetics and cell types. GXF-111 induces G1 phase cell cycle arrest, downregulates c-Myc expression, upregulates p21 expression, and exhibits antiproliferative activity against a variety of cancer cell lines. GXF-111 can serve as a research tool for cancer-related studies .
Cat. No.: HY-181189
CAS No.: 2412988-53-3
Research Areas:
Lenalidomide-C7-NH2 is a synthetic E3 ligase ligand-connector conjugate that can be used for the synthesis of PROTACs, such as GXF-111 (HY-153414). GXF-111 is a BRD3/BRD4-L PROTAC degrader with anti-tumor activity .
Cat. No.: HY-181900
CAS No.: 3072863-05-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 226 is a synthetic E3 ligase ligand-linker conjugate that can be used to synthesize PROTACs, such as PROTAC IRAK3 degrader-2 (HY-181898). GXF-111 is a IRAK PROTAC degrader with anti-tumor activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
