1 Result for "

Gy-CATH

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Gy-CATH" in MCE Product Catalog:

Gy-CATH
Gy-CATH
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Art. -Nr.: HY-P11467
Target:  

Bacterial p38 MAPK NF-κB PERK JNK

Forschungsgebiete:  

Cardiovascular Disease Infection

Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice .
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