1 Result for "

ICP 723

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ICP 723" in MCE Product Catalog:

Cat. No.: HY-148811
CAS No.: 2403703-30-8
Synonyms: ICP-723
Target:  

c-Met/HGFR Trk Receptor

Research Areas:  

Cancer

Zurletrectinib is a brain-penetrant, orally active TRK inhibitor (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Zurletrectinib exhibits stronger activity as a consequence of its augmented binding affinity for TRK kinases. Zurletrectinib exhibits higher activity against most TRK inhibitor resistance mutations (13 out of 18 mutations). Zurletrectinib can be used for the study of glioma .
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