2403703-30-8
Chemical Structure
Zurletrectinib
Synonym(s): ICP-723
- CAS No.: 2403703-30-8
- Formula:C19H19F2N7O2
- Molecular Weight:415.40
IUPAC Name: (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(2-azidoethoxy)-2-(hydroxymethyl)tetrahydrofuran-3-ol
InChIKey: OIBWCYRRWAMTRW-ITDIGPHOSA-N
SMILES: O=C1NC2=C3N=C(N4[C@@](C[C@@](F)([H])C4)([H])C5=CC(F)=CN=C5O[C@](C)([H])CN1)C=CN3N=C2
Biological Activity: Zurletrectinib is a brain-penetrant, orally active TRK inhibitor (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Zurletrectinib exhibits stronger activity as a consequence of its augmented binding affinity for TRK kinases. Zurletrectinib exhibits higher activity against most TRK inhibitor resistance mutations (13 out of 18 mutations). Zurletrectinib can be used for the study of glioma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zurletrectinib | 99.32% | Zurletrectinib is a brain-penetrant, orally active TRK inhibitor (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Zurletrectinib exhibits stronger activity as a consequence of its augmented binding affinity for TRK kinases. Zurletrectinib exhibits higher activity against most TRK inhibitor resistance mutations (13 out of 18 mutations). Zurletrectinib can be used for the study of glioma. | ||||||||||||||||||||
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Keywords
