1 Result for "

IMPDH-IN-4

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IMPDH-IN-4" in MCE Product Catalog:

Cat. No.: HY-161712
CAS No.: 2427862-70-0
Target:  

IMPDH

Research Areas:  

Cancer

IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .
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