1 Result for "

Isoandrographolide

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Isoandrographolide" in MCE Product Catalog:

Isoandrographolide
Isoandrographolide
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Cat. No.: HY-N10359
CAS No.: 4176-96-9
Category:  

Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NOD-like Receptor (NLR) Caspase Akt GSK-3 β-catenin

Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and AKT/GSK-3β/β-catenin pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3, ASC, and caspase-1, and reduces the levels of phosphorylated AKT, phosphorylated GSK-3β, and β-catenin. Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease .
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