3 Results for "

K562/ADR

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "K562/ADR" in MCE Product Catalog:

5
Paris saponin VII
Paris saponin VII
0 Images
5 Cited Publications
Cat. No.: HY-N3584
CAS No.: 68124-04-9
Synonyms: Chonglou Saponin VII
Category:  

Liliaceae  Trillium tschonoskii Maxim. Plants Disease Research Fields Cancer Steroids

Target:  

Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
loading...
    loading...
View All Sizes
Paris saponin VII (Standard)
Paris saponin VII (Standard)
0 Images
Cat. No.: HY-N3584R
CAS No.: 68124-04-9
Synonyms: Chonglou Saponin VII (Standard)
Category:  

Liliaceae  Trillium tschonoskii Maxim. Plants Steroids

Target:  

Reference Standards Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis

Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
loading...
    loading...
View All Sizes
PD 404182 (Standard)
PD 404182 (Standard)
0 Images
Cat. No.: HY-16958R
CAS No.: 72596-74-8
Target:  

Antibiotic Dimethylargininase (DDAH) Reference Standards

Research Areas:  

Inflammation/Immunology

Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
loading...
    loading...
View All Sizes
Assay Types