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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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KP-4 cells

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162749A
    G9D-4 TFA

    		PROTACs Histone Methyltransferase Apoptosis Cancer
    G9D-4 TFA is a G9a PROTAC degrader. G9D-4 TFA induces G9a degradation, reduces H3K9me2 levels, and prevents GLP interference via the CRBN ternary complex, proteasome and ubiquitin-like modification-dependent pathways. G9D-4 TFA exerts antiproliferative activity and induces Apoptosis in pancreatic cancer cells. G9D-4 TFA can be used for research on pancreatic cancer .
    G9D-4 TFA
  • HY-162749
    G9D-4

    		PROTACs Histone Methyltransferase Apoptosis Cancer
    G9D-4 is a G9a PROTAC degrader. G9D-4 induces G9a degradation, reduces H3K9me2 levels, and prevents GLP interference via the CRBN ternary complex, proteasome and ubiquitin-like modification-dependent pathways. G9D-4 exerts antiproliferative activity and induces Apoptosis in pancreatic cancer cells. G9D-4 can be used for research on pancreatic cancer .
    G9D-4
  • HY-158152
    PROTAC CRBN ligand-2

    		Ligands for E3 Ligase Cancer
    PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC50 of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV .
    PROTAC CRBN ligand-2
  • HY-182400
    AGI-25696

    		Methionine Adenosyltransferase (MAT) Cancer
    AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer .
    AGI-25696

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