2 Results for "

KRAS alterations

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "KRAS alterations" in MCE Product Catalog:

Cat. No.: HY-156002
CAS No.: 2676177-63-0
Purity:  99.20%
Synonyms: Paluratide
Target:  

Ras ERK

Research Areas:  

Cancer

LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer .
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Cat. No.: HY-183553
CAS No.: 2874214-01-2
Target:  

Ras

Research Areas:  

Cancer

AUBE00 is an orally active, selective cyclic peptide pan-KRAS inhibitor. AUBE00 selectively binds to the OFF state of KRAS. AUBE00 exhibits anticancer activity against RAS wild-type colorectal cancer. The combination of AUBE00 with Cetuximab (HY-P9905) produces a synergistic antiproliferative effect .
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