![7-Azaspiro[3.5]nonane-2-ethanol](https://file.medchemexpress.com/product_pic/hy-w382009.gif "Click to View 7-Azaspiro[3.5]nonane-2-ethanol Product Detail")
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3 Results for "
KTX951
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "KTX951" in MCE Product Catalog:
KTX-951 is an orally active PROTAC degrader of IRAK4 and IMiD (Ikaros/Aiolos) substrates (Kd = 3.5 nM). KTX-951 induces IRAK4 degradation, and the degradation efficiency is independent of IRAK4 binding affinity. The DC50 values of KTX-951 for IRAK4, Ikaros and Aiolos are 18 nM, 14 nM and 13 nM, respectively. The IC50 of KTX-951 against OCl-Ly10 CTG is 35 nM. KTX-951 exhibits antitumor activity .
Cat. No.: HY-W382009
CAS No.: 1370211-12-3
Target:
Research Areas:
7-Azaspiro[3.5]nonane-2-ethanol is a PROTAC linker can be used in the synthesis of PROTAC, KTX-951 (HY-148290) .
Cat. No.: HY-48932
CAS No.: 2573304-97-7
Research Areas:
IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290) .
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Protocols
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