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Kevetrin

" in MedChemExpress (MCE) Product Catalog:

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Isotope-Labeled Compounds

Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-16271
    Kevetrin hydrochloride
    4 Publications Verification

    4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride

    		 MDM-2/p53 Apoptosis Cancer
    Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells .
    Kevetrin hydrochloride
  • HY-16271S
    Kevetrin-13C2,15N3 hydrochloride

    4-Isothioureidobutyronitrile-13C2,15N3 hydrochloride; thioureidobutyronitrile-13C2,15N3 hydrochloride

    		 Isotope-Labeled Compounds MDM-2/p53 Cancer
    Kevetrin (hydrochloride)- 13C2, 15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
    Kevetrin-13C2,15N3 hydrochloride
  • HY-16270
    Kevetrin

    3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile

    		 Apoptosis MDM-2/p53 Cancer
    Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that exhibits p53-dependent and p53-independent antitumor activity. In TP53 wild-type models, Kevetrin activates and stabilizes the p53 protein by altering the processing of MDM2, thereby inducing cell cycle arrest and apoptosis. Kevetrin shows higher sensitivity in mutant models. Kevetrin is applicable for the research of various cancers including acute myeloid leukemia and breast cancer .
    Kevetrin

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