500863-50-3
Chemical Structure
Kevetrin
Synonym(s): 3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile
- CAS No.: 500863-50-3
- Formula:C5H9N3S
- Molecular Weight:143.21
IUPAC Name: 3-cyanopropyl carbamimidothioate
InChIKey: PRDJGNVQBVXXEO-UHFFFAOYSA-N
SMILES: N#CCCCSC(=N)N
Biological Activity: Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that exhibits p53-dependent and p53-independent antitumor activity. In TP53 wild-type models, Kevetrin activates and stabilizes the p53 protein by altering the processing of MDM2, thereby inducing cell cycle arrest and apoptosis. Kevetrin shows higher sensitivity in mutant models. Kevetrin is applicable for the research of various cancers including acute myeloid leukemia and breast cancer[1].
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Kevetrin | Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that exhibits p53-dependent and p53-independent antitumor activity. In TP53 wild-type models, Kevetrin activates and stabilizes the p53 protein by altering the processing of MDM2, thereby inducing cell cycle arrest and apoptosis. Kevetrin shows higher sensitivity in mutant models. Kevetrin is applicable for the research of various cancers including acute myeloid leukemia and breast cancer. | |||||||||||||||||||||
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Keywords
