2300178-72-5
Chemical Structure
Kevetrin-13C2,15N3 hydrochloride
Synonym(s): 4-Isothioureidobutyronitrile-13C2,15N3 hydrochloride; thioureidobutyronitrile -13C2,15N3 hydrochloride
- CAS No.: 2300178-72-5
- Formula:C313C2H10Cl15N3S
- Molecular Weight:184.64
IUPAC Name: 3-(cyano-13C-15N)propyl carbamimidothioate-13C-15N2 hydrochloride
InChIKey: NCXJZJFDQMKRKM-CBWHUSCUSA-N
SMILES: [15NH2][13C](SCCC[13C]#[15N])=[15NH].Cl
Biological Activity: Kevetrin-13C2,15N3 (4-Isothioureidobutyronitrile-13C2,15N3) hydrochloride is the 15N, 13C-labeled Kevetrin (hydrochloride) (HY-16271). Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Kevetrin-13C2,15N3 hydrochloride | Kevetrin-13C2,15N3 (4-Isothioureidobutyronitrile-13C2,15N3) hydrochloride is the 15N, 13C-labeled Kevetrin (hydrochloride) (HY-16271). Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kevetrin hydrochloride | 98.0% | Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.96
HY-16270Kevetrin -
Similarity Score 0.76
HY-B1478Dimaprit dihydrochloride -
Similarity Score 0.75
HY-W2431764-Aminobutanenitrile hydrochloride -
Similarity Score 0.74
HY-100967SKF 91488 dihydrochloride -
Similarity Score 0.74
HY-131929AE-ITU dihydrobromide -
Similarity Score 0.71
HY-108977VUF 8430 -
Similarity Score 0.71
HY-186038Cyanoethyl dimethyldithiocarbamate -
Similarity Score 0.70
HY-W2819502-(Carbamimidoylsulfanyl)acetic acid hydrochloride -
Similarity Score 0.70
HY-158735Thioarginine hydrobromide -
Explore the MedChemAI to find more analogs
References
- [1]. Napolitano R, et al. Kevetrin induces apoptosis in TP53 wildtype and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Oct;44(4):1561-1573. [Content Brief]
- [2]. Kumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independKumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies. Cancer Research. 2017. 77(13 Supplement), 3221-3221.
