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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
LDL-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "LDL-IN-2" in MCE Product Catalog:
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Research Areas:
LDL-IN-2 (compound 3) is an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation .
Cat. No.: HY-N0339S
CAS No.: 84759-06-8
Cat. No.: HY-123016A
CAS No.: 33783-76-5
Target:
Research Areas:
(±)9-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL.2 Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 9-HODE cholesteryl ester.
2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways [2].
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
