141-46-8
Chemical Structure
2-Hydroxyacetaldehyde
- CAS No.: 141-46-8
- Formula:C2H4O2
- Molecular Weight:60.05
InChIKey: WGCNASOHLSPBMP-UHFFFAOYSA-N
SMILES: OCC=O
Biological Activity: 2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways[1][2].
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2-Hydroxyacetaldehyde | 2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways. | |||||||||||||||||||||
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2-Hydroxyacetaldehyde-13C2 | 2-Hydroxyacetaldehyde-13C2 is the 13C-labeled 2-Hydroxyacetaldehyde (HY-28911). | |||||||||||||||||||||
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Glycolaldehyde-1-13C | 99.0% | Glycolaldehyde-1-13C is the 13C labeled Glycolaldehyde. | ||||||||||||||||||||
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- [1]. Shepherd J, Packard C J. Receptor-independent low-density lipoprotein catabolism[M]//Methods in enzymology. Academic Press, 1986, 129: 566-590.
- [2]. Harman CE, et al. Atmospheric production of glycolaldehyde under hazy prebiotic conditions. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 2013 Apr;43(2):77-98. [Content Brief]
