2-Hydroxyacetaldehyde
2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways.
For research use only. We do not sell to patients.
- CAS No.: 141-46-8
- Formula: C2H4O2
- Molecular Weight:60.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Hydroxyacetaldehyde (80 mM; 2.5-21 h at 37°C) rapidly modifies lysine residues on human LDL[1].
2-hydroxyacetaldehyde-modified human LDL (100 μg/mL) does not compete with native LDL for LDL receptors on cultured normal human fibroblasts, resulting in a degradation rate of 94% relative to the no-competitor control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141-46-8
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Molecular Weight 60.05
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Formula C2H4O2
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SMILES
OCC=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Hydroxyacetaldehyde Related Classifications
HY-28911 Related Classifications
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