1 Result for "

LI633

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "LI633" in MCE Product Catalog:

Cat. No.: HY-185007
CAS No.: 1849624-82-3
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain .
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