2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. LI-633

LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain.

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LI-633

LI-633 Chemical Structure

CAS No. : 1849624-82-3

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Description

LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain[1].

Molecular Weight

355.75

Formula

C18H11ClFN3O2
CAS No.
SMILES

O=C(C1=CN(C2=C(C(C3=C(C=CC=C3)F)=NC4)C=C(Cl)C=C2)C4=N1)O
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LI-633 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LI-6331849624-82-3LI633LI 633GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA PAMα5β2γ2α3β2γ2visceral painselective and orally activeInhibitorinhibitorinhibit

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