1849624-82-3
Chemical Structure
LI-633
- CAS No.: 1849624-82-3
- Formula:C18H11ClFN3O2
- Molecular Weight:355.75
InChIKey: OMJNIBWVQQKGJT-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2=C(C(C3=C(C=CC=C3)F)=NC4)C=C(Cl)C=C2)C4=N1)O
Biological Activity: LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain[1].
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LI-633 | LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain. | |||||||||||||||||||||
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Keywords
