2 Results for "

Largazole

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Largazole" in MCE Product Catalog:

Cat. No.: HY-13906
CAS No.: 1009815-87-5
Synonyms: (+)-Largazole
Largazole ((+)-Largazole) is an orally active, blood-brain barrier-permeable class I histone deacetylase (HDAC) inhibitor with in vivo anticancer activity and osteogenic efficacy. As a prodrug, Largazole hydrolyzes to Largazole thiol (HY-170890), which has a Ki value of 0.07 nM against human HDAC2. Largazole regulates the cell cycle, induces apoptosis, upregulates tumor suppressors and osteoblast differentiation markers, inhibits osteoclast formation, and upregulates neuroprotection-related genes. Largazole can be used in the research of various cancers including colorectal cancer, as well as neurodegenerative diseases .
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Cat. No.: HY-170890
CAS No.: 1132667-11-8
Target:  

HDAC

Research Areas:  

Neurological Disease Cancer

Largazole thiol, the active form of Largazole (HY-13906), is a potent, selective and brain-penetrant class I HDAC inhibitor. Largazole thiol. Largazole thiol exerts antitumor and neuroprotective effects. Largazole thiol can be used for research of Glioblastoma .
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