2 Results for "

Linderane

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Linderane" in MCE Product Catalog:

Linderane
Linderane
0 Images
Cat. No.: HY-N0688
CAS No.: 13476-25-0
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.

Target:  

ERK STAT Phosphodiesterase (PDE) PKA p38 MAPK Keap1-Nrf2 JAK Interleukin Related Apoptosis Cannabinoid Receptor

Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety .
loading...
    loading...
View All Sizes
Linderane (Standard)
Linderane (Standard)
0 Images
Cat. No.: HY-N0688R
CAS No.: 13476-25-0
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm.

Target:  

Reference Standards ERK STAT Phosphodiesterase (PDE) PKA p38 MAPK Keap1-Nrf2 JAK Interleukin Related Apoptosis Cannabinoid Receptor

Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety .
loading...
    loading...
View All Sizes
Assay Types