13476-25-0
Chemical Structure
Linderane
- CAS No.: 13476-25-0
- Formula:C15H16O4
- Molecular Weight:260.29
IUPAC Name: (10S,10aR,Z)-5,9-dimethyl-3,6,10,10a-tetrahydro-2H-10,1a-(epoxymethano)oxireno[2',3':4,5]cyclodeca[1,2-b]furan-12-one
InChIKey: KBMSVODXFLAQNJ-JELGAPFCSA-N
SMILES: O=C(O[C@@]1([H])C2=C3OC=C2C)C4(CC/C=C(C)\C3)[C@@H]1O4
Biological Activity: Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Linderane | 98.61% | Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety. | ||||||||||||||||||||
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Linderane (Standard) | ≥98% | Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety. | ||||||||||||||||||||
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- [1]. Xie W, et al. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3. Frontiers in pharmacology. 2018;9:476. [Content Brief]
- [2]. Zhang H, et al. Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage. Life sciences. 2019 Sep 15;233:116732. [Content Brief]
- [3]. Lai H, et al. Linderane from Lindera aggregata attenuates ulcerative colitis by suppressing IL-6/STAT3-mediated Th17 differentiation and apoptosis resistance. Journal of ethnopharmacology. 2026 Feb 28;357:120965. [Content Brief]
- [4]. Chen Y, et al. Linderane Attenuates Complete Freund's Adjuvant-Induced Pain and Anxiety in Mice by Restoring Anterior Cingulate Cortex Microglia M2 Polarization through Activating Cannabinoid 2 Receptor. ACS pharmacology & translational science. 2024 Mar 08;7(3):797-808. [Content Brief]
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