2 Results for "

MDM2-MDMX complex

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "MDM2-MDMX complex" in MCE Product Catalog:

Cat. No.: HY-148106
CAS No.: 642072-49-9
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription .
loading...
    loading...
Cat. No.: HY-P11490
Target:  

MDM-2/p53

Research Areas:  

Inflammation/Immunology Cancer

DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53 signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 +/CD8 + cytotoxic T cells and suppressing CD4 +/CD25 + regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .
loading...
    loading...