DPMI-ω
DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53 signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3+/CD8+ cytotoxic T cells and suppressing CD4+/CD25+ regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma.
For research use only. We do not sell to patients.
- Formula: C82H114ClN17O20
- Molecular Weight:1693.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 1693.34
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Formula C82H114ClN17O20
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Sequence
d-(Glu-Phe-Trp-Tyr-Val-Glu-{p-Cl-Phe}-Glu-Lys-Leu-Leu-Arg)
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Sequence Shortening
d-(EFWYVE-{p-Cl-Phe}-EKLLR)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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