642072-49-9
642072-49-9
Chemical Structure
MEL23
- CAS No.: 642072-49-9
- Formula:C19H22N4O3
- Molecular Weight:354.40
IUPAC Name: 1-butyl-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
InChIKey: QHZNHPZINXHFDK-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1CCCC)=O)=O
Biological Activity: MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription[1].
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MEL23 | MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription. | |||||||||||||||||||||
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References
Keywords
