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MS-243

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-181728
    MS243

    		PROTACs Ras Cancer
    MS243 is a potent KRAS G12D PROTAC degrader with a DC50 of 4.2 nM. MS243 promotes the proximity between KRAS G12D and the VHL E3 ubiquitin ligase, drives the ubiquitination and proteasomal degradation of KRAS G12D, and inhibits the proliferation of cancer cells harboring KRAS G12D. MS243 can be used in the research of KRAS G12D-carrying cancers, such as colon cancer and pancreatic cancer .
    MS243
  • HY-181733
    KRAS G12D ligand-3

    		Ligands for Target Protein for PROTAC Ras Cancer
    KRAS G12D ligand-3 is a KRAS G12D PROTAC ligand. KRAS G12D ligand-3 can be conjugated with E3 ligase Ligand (HY-170348) and linke (HY-W895436) to synthesize KRAS G12D PROTAC degrader MS243 (HY-181728). MS243 can be used for cancer research .
    KRAS G12D ligand-3
  • HY-181734
    E3 Ligase Ligand-linker Conjugate 224

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 224 is an E3 Ligase Ligand-Linker Conjugate that incorporates a ligand for VHL (HY-170348) and a PROTAC linker (HY-W895436). E3 Ligase Ligand-linker Conjugate 224 can be used for synthesis of KRAS G12D PROTAC degrader MS243 (HY-181728) .
    E3 Ligase Ligand-linker Conjugate 224

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