2 Results for "

MV3 cells

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "MV3 cells" in MCE Product Catalog:

DSPE-PEG2000-TAT
DSPE-PEG2000-TAT
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Cat. No.: HY-172279A
DSPE-PEG2000-TAT is a cell-penetrating peptide-modified PEGylated phospholipid conjugate and cellular uptake enhancer. DSPE-PEG2000-TAT forms via conjugation of Cys-TAT to DSPE-PEG2000-Mal. DSPE-PEG2000-TAT enhances liposomal cellular uptake and siRNA transfection efficiency in glomerular mesangial and macrophage cells. DSPE-PEG2000-TAT can be used for drug delivery .
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Kuwanon H
Kuwanon H
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Cat. No.: HY-N2600
CAS No.: 76472-87-2
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer Morus alba Linn.

Target:  

Bombesin Receptor Akt mTOR ERK p38 MAPK Apoptosis Autophagy

Kuwanon H is a selective non-peptide bombesin receptor antagonist and platelet activation inhibitor. Kuwanon H also acts as a specific antagonist of GRP-preferring receptors, with a Ki value of 290 nM for mouse GRP-R and 6500 nM for rat NMB-R. Kuwanon H inhibits the phosphorylation of AKT, mTOR, ERK, cPLA2 and p38, and upregulates TRIB3. It induces endoplasmic reticulum stress, apoptosis and autophagosome formation. Kuwanon H blocks calcium mobilization, mitogenic signaling, DNA synthesis, dense granule secretion, thromboxane A2 generation and integrin αIIb/β3 activity. It inhibits collagen-induced platelet aggregation and fibronectin adhesion, and delays clot retraction. Kuwanon H inhibits melanoma cell growth in vitro and in vivo, and enhances the sensitivity of melanoma cells to CDDP. It can be used in research related to melanoma, small cell lung cancer and thrombosis .
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