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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Maytansinoid DM4
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Maytansinoid DM4" in MCE Product Catalog:
Cat. No.: HY-100503
CAS No.: 799840-96-3
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Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC .
3
3 Cited Publications
Synonyms: IMGN853 (solution)
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Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
1
1 Cited Publications
Cat. No.: HY-P99542
CAS No.: 2254086-60-5
Synonyms: SAR-408701; HuMAb2-3-SPDB-DM4
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1
1 Cited Publications
Synonyms: BT-062; nBT062-DM4
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1
1 Cited Publications
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S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule .
Synonyms: BAY 94-9343
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Cat. No.: HY-143985S
Cat. No.: HY-143992S
Cat. No.: HY-143993S
Cat. No.: HY-P991940
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
