Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Midazolam
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Midazolam" in MCE Product Catalog:
Cat. No.: HY-18642
CAS No.: 1390637-82-7
Synonyms: PF-4981517
Target:
Research Areas:
CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC50 values for Midazolam 1’-hydroxylase activity are 0.03 μM, 17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on agent metabolism .
Cat. No.: HY-W002172
CAS No.: 784-38-3
Target:
Research Areas:
2-Amino-5-chloro-2'-fluorobenzophenone is a precursor in the synthesis of Midazolam.
Cat. No.: HY-117789
CAS No.: 112560-33-5
Synonyms: keto-ITZ
Target:
Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam .
Synonyms: ML368
Target:
SR9186 (ML368) is a selective CYP3A4 inhibitor with IC50 values of 9, 4, and 38 nM for Midazolam → 1'-hydroxymidazolam, Testosterone → 6β-hydroxytestosterone, and Vincristine → Vincristine M1, respectively. SR-9186 inhibits the development of hepatic-stage P. falciparum and blocks ivermectin metabolism. SR-9186 can be used in breast cancer research .
Cat. No.: HY-W740139
CAS No.: 1276584-44-1
Cat. No.: HY-116859
CAS No.: 78756-03-3
Target:
Research Areas:
Ro 14-7437 is a potent and selective potentiating antagonist of Midazolam .
Cat. No.: HY-W740707
CAS No.: 1215321-98-4
Cat. No.: HY-18642A
Synonyms: (R)-PF-4981517
Target:
Research Areas:
(R)-CYP3cide ((R)-PF-4981517) is the R-isomer of CYP3cide (HY-18642). CYP3cide is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) .
Cat. No.: HY-124626
CAS No.: 147780-50-5
Target:
Research Areas:
(R)-(+)-Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. (R)-(+)-Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. (R)-(+)-Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R)-(+)-Mequitazine can be used in the study of various allergic diseases .
Cat. No.: HY-16641
CAS No.: 1315490-71-1
JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research .
Cat. No.: HY-W740662
CAS No.: 64740-68-7
Cat. No.: HY-W879508
CAS No.: 173026-17-0
Synonyms: BXT-51072
Research Areas:
ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
