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Results for "

Midazolam

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18642
    CYP3cide

    PF-4981517

    		 Cytochrome P450 Others
    CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC50 values for Midazolam 1’-hydroxylase activity are 0.03 μM, 17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on agent metabolism .
    CYP3cide
  • HY-W002172
    2-Amino-5-chloro-2'-fluorobenzophenone

    		Drug Intermediate Neurological Disease
    2-Amino-5-chloro-2'-fluorobenzophenone is a precursor in the synthesis of Midazolam.
    2-Amino-5-chloro-2'-fluorobenzophenone
  • HY-117789
    Keto-itraconazole

    keto-ITZ

    		 Cytochrome P450 Infection Cancer
    Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam .
    Keto-itraconazole
  • HY-120696
    SR9186

    ML368

    		 Cytochrome P450 Parasite Infection Cancer
    SR9186 (ML368) is a selective CYP3A4 inhibitor with IC50 values of 9, 4, and 38 nM for Midazolam → 1'-hydroxymidazolam, Testosterone → 6β-hydroxytestosterone, and Vincristine → Vincristine M1, respectively. SR-9186 inhibits the development of hepatic-stage P. falciparum and blocks ivermectin metabolism. SR-9186 can be used in breast cancer research .
    SR9186
  • HY-148002
    1'-Hydroxy Midazolam-β-D-glucuronide

    		Drug Metabolite Others
    1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite .
    1'-Hydroxy Midazolam-β-D-glucuronide
  • HY-W740139
    4-Hydroxy midazolam methanoate-d5

    		Isotope-Labeled Compounds GABA Receptor Drug Metabolite Neurological Disease
    4-Hydroxy midazolam methanoate-d5 is the deuterium labeled 4-Hydroxymidazolam (HY-100050). 4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.
    4-Hydroxy midazolam methanoate-d5
  • HY-116859
    Ro 14-7437

    		GABA Receptor Neurological Disease
    Ro 14-7437 is a potent and selective potentiating antagonist of Midazolam .
    Ro 14-7437
  • HY-W740707
    Midazolam 2,5-Dioxide-d6

    		Isotope-Labeled Compounds Others
    Midazolam 2,5-Dioxide-d6 is the deuterium labeled 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-DioxideMidazolam 2,5-Dioxide (HY-W776994).
    Midazolam 2,5-Dioxide-d6
  • HY-18642A
    (R)-CYP3cide

    (R)-PF-4981517

    		 Cytochrome P450 Others
    (R)-CYP3cide ((R)-PF-4981517) is the R-isomer of CYP3cide (HY-18642). CYP3cide is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) .
    (R)-CYP3cide
  • HY-124626
    (R)-(+)-Mequitazine

    		Histamine Receptor Inflammation/Immunology
    (R)-(+)-Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. (R)-(+)-Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. (R)-(+)-Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R)-(+)-Mequitazine can be used in the study of various allergic diseases .
    (R)-(+)-Mequitazine
  • HY-16641
    JAK1-IN-17

    		JAK Cancer
    JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research .
    JAK1-IN-17
  • HY-W879508
    ALT-2074

    BXT-51072

    		 Cytochrome P450 Glutathione Peroxidase Inflammation/Immunology
    ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome .
    ALT-2074

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