1 Result for "

NGD9002

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "NGD9002" in MCE Product Catalog:

Cat. No.: HY-118935
CAS No.: 666256-06-0
Target:  

Adrenergic Receptor

Research Areas:  

Inflammation/Immunology

NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension .
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