666256-06-0
Chemical Structure
NGD9002 free base
- CAS No.: 666256-06-0
- Formula:C20H31N5O
- Molecular Weight:357.49
IUPAC Name: 5-(6-isopropyl-2-(methylamino)pyridin-3-yl)-3-methoxy-6-methyl-N-(pentan-3-yl)pyrazin-2-amine
InChIKey: WOFKFSYSTXMXQU-UHFFFAOYSA-N
SMILES: CC1=C(N=C(C(NC(CC)CC)=N1)OC)C2=CC=C(N=C2NC)C(C)C
Biological Activity: NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension[1].
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NGD9002 free base | NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension. | |||||||||||||||||||||
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