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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
NR5A2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "NR5A2" in MCE Product Catalog:
5
Target:
Research Areas:
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers .
2
2 Cited Publications
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RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively . RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .
Research Areas:
LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease .
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ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer .
Cat. No.: HY-RS09554
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Research Areas:
NR5A2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR5A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17146
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Research Areas:
Nr5a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr5a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23595
Target:
Research Areas:
Nr5a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr5a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P810473
Synonyms: Nuclear Receptor Subfamily 5 Group A Member 2, LRH-1, FTZ-F1beta, FTZ-F1, HB1F-2, HB1F, B1F2, LRH1, FTF, CYP7A Promoter-Binding Factor, B1F, CPF, B1-Binding Factor, Hepatocyte Transcription Factor Which Activates Enhancer II Of Hepatitis B Virus, Nuclear Receptor Subfamily 5, Group A, Member 2, Fetoprotein-Alpha 1 (AFP) Transcription Factor, Alpha-1-Fetoprotein Transcription Factor, Hepatocytic Transcription Factor HB1F-3, Hepatocytic Transcription Factor, Liver Receptor Homolog-1, Liver Receptor Homolog 1, B1-Binding Factor
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
